I often tell myself and my students: medicine is the most human of all the sciences that is stuck with the least human of all the experiments: and that is the randomized trial.
Randomization doesn’t exist because doctors are malign or medicine is nasty it exists precisely for the utterly opposite reason: because we hope too much.
We’re so hopeful, that we want things to work so badly-especially against cancer-we want things to work so badly that we’ll trick ourselves to believing that they’re working.
And there’s nothing as toxic or as lethal as that trick: the trick of hope.
— Dr. Siddhartha Mukherjee in PBS’ Cancer: The Emperor of All Maladies